Medications


Levodopa oral inhalation powder

What is this medicine?

LEVODOPA (lee voe DOE pa) is used to treat 'off' episodes in advanced Parkinson's disease. These episodes affect your ability to move or perform tasks.

How should I use this medicine?

This medicine is used in a special inhaler. Do NOT swallow the capsules. Follow the directions on the prescription label. Do not use it more often than directed. Do not stop taking except on your doctor's advice. Make sure that you are using your inhaler correctly. Ask your doctor or health care provider if you have any questions.

Talk to your pediatrician about the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • changes in emotions or moods

  • changes in vision

  • eye pain

  • falling asleep during normal activities like driving

  • fast, irregular heartbeat

  • hallucination, loss of contact with reality

  • new or increased gambling urges, sexual urges, uncontrolled spending, binge or compulsive eating, or other urges

  • signs and symptoms of infection like fever; chills; cough; sore throat

  • signs and symptoms of low blood pressure like dizziness; feeling faint or lightheaded, falls; unusually weak or tired

  • signs and symptoms of neuroleptic malignant syndrome (NMS) like confusion; fast, irregular heartbeat; high fever; increased sweating; uncontrollable head, mouth, neck, arm, or leg movements; stiff muscles

  • trouble passing urine

  • trouble sleeping

  • uncontrollable movements of the arms, face, head, mouth, neck, or upper body

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • cough during or after using inhaler

  • dark color to urine, saliva, sweat, or other body fluids

  • headache

  • nausea

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • MAOIs like Marplan, Nardil, and Parnate

This medicine may also interact with the following medications:

  • antihistamines for allergy, cough, and cold

  • antipsychotics like risperidone and haloperidol

  • certain medicines for anxiety or sleep

  • certain medicines for depression like amitriptyline, fluoxetine, sertraline

  • certain medicines for seizures like phenobarbital, primidone

  • general anesthetics like halothane, isoflurane, methoxyflurane, propofol

  • iron salts or multivitamins with iron salts

  • isoniazid

  • linezolid

  • local anesthetics like lidocaine, pramoxine, tetracaine

  • medicines that relax muscles for surgery

  • metoclopramide

  • narcotic medicines for pain

  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine

  • rasagiline

  • safinamide

  • selegiline

  • yohimbine

What if I miss a dose?

This does not apply. This medicine is not for regular use.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep capsules in the foil pack until you are ready to use. Do not store capsules inside the inhaler for a future dose. Keep the inhaler and capsules dry. Throw away the inhaler after all capsules in the carton have been used. Use the new inhaler that comes with your prescription refill. Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • feel sleepy or have fallen asleep suddenly during the day

  • glaucoma

  • heart disease

  • have trouble controlling your muscles (dyskinesia)

  • have urges that you are unable to control (for example, gambling, spending money, or eating)

  • if you often drink alcohol

  • liver disease

  • lung or breathing disease, like asthma

  • mental illness

  • narcolepsy

  • stomach or intestine problems

  • trouble sleeping

  • an unusual or allergic reaction to levodopa, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your healthcare professional for regular checks on your progress. Tell your healthcare professional if your symptoms do not start to get better or if they get worse.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. If you find that you have sudden feelings of wanting to sleep during normal activities, like cooking, watching television, or while driving or riding in a car, you should contact your healthcare provider.

There have been reports of increased sexual urges or other strong urges such as gambling while taking this medicine. If you experience any of these while taking this medicine, you should report this to your healthcare professional as soon as possible.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2019 Elsevier
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