Medications


Glasdegib oral tablet

What is this medicine?

GLASDEGIB (glas deg ib) is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat acute myelogenous leukemia.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take this medicine with or without food. However, you should always take it the same way. Do not cut, crush, or chew this medicine. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • fever or chills, sore throat

  • mouth sores

  • muscle pain

  • signs and symptoms of bleeding such as bloody or black, tarry stools; red or dark brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eyes, gums, or nose

  • signs and symptoms of a dangerous change in heartbeat or heart rhythm like chest pain; dizziness; fast, irregular heartbeat; palpitations; feeling faint or lightheaded; falls, breathing problems

  • unusually weak or tired

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

  • change in taste

  • constipation

  • nausea

  • swelling of the ankles, feet, or hands

  • tiredness

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • cisapride

  • dofetilide

  • dronedarone

  • pimozide

  • thioridazine

This medicine may also interact with the following medications:

  • antiviral medicines for HIV or AIDS

  • apalutamide

  • certain antibiotics like clarithromycin, chloramphenicol, telithromycin, and dalfopristin; quinupristin

  • certain medicines for fungal infections like itraconazole, ketoconazole, posaconazole, and voriconazole

  • certain medicines for seizures like carbamazepine, fosphenytoin/phenytoin, phenobarbital, and primidone

  • conivaptan

  • grapefruit juice

  • idelalisib

  • lumacaftor; ivacaftor

  • mifepristone

  • mitotane

  • nefazodone

  • other medicines that prolong the QT interval (cause an abnormal heart rhythm)

  • ribociclib

  • rifampin

  • St.John's Wort

What if I miss a dose?

If you miss a dose, take it as soon as you can. If your next dose is to be taken in less than 12 hours, then do not take the missed dose. Take the next dose at your regular time. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • heart disease

  • history of irregular heartbeat

  • history of a muscle disorder

  • kidney disease

  • liver disease

  • low or high levels of electrolytes in the blood

  • an unusual or allergic reaction to glasdegib, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

You may need blood work done while you are taking this medicine.

Do not become pregnant while taking this medicine or for a least 30 days after stopping it. Women should inform their healthcare professional if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine or for at least 30 days after stopping it. Do not donate sperm while taking this medicine and for at least 30 days after you stop taking it. There is a potential for serious effects to an unborn child. Talk to your healthcare professional for more information.

Do not breast-feed an infant while taking this medicine or for at least 30 days after stopping it.

This medicine may make it more difficult to father a child. Talk to your healthcare professional if you are concerned about your fertility.

Do not give blood while taking this medicine or for 30 days after stopping it.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2019 Elsevier
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