Medications


Doravirine; lamivudine; tenofovir disoproxil fumarate Tablets

What is this medicine?

DORAVIRINE; LAMIVUDINE; TENOFOVIR DISOPROXIL FUMARATE (door ah VIR een; la ME vyoo deen; te NOE fo veer) is 3 antiretroviral medicines in 1 tablet. It is used with other medicines to treat HIV. This medicine is not a cure for HIV. This medicine can lower, but not fully prevent, the risk of spreading HIV to others.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take your medicine more often than directed. For your anti-HIV therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the HIV virus resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • bone or muscle pain

  • changes in behavior like severe depression, strange thoughts, thoughts of suicide, or angry behavior

  • muscle pain or weakness

  • trouble passing urine or changes in the amount of urine

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

  • diarrhea

  • difficulty sleeping, strange dreams

  • dizziness

  • rash

  • weight gain around waist, back, or thinning of face, arms, legs

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • any medicine that contains efavirenz, emtricitabine, etravirine, lamivudine, nevirapine, or tenofovir

  • apalutamide

  • certain antibiotics like rifapentine, rifampin

  • enzalutamide

  • medicines for seizures like carbamazepine, oxcarbazepine, phenobarbital, phenytoin, primidone

  • mitotane

  • St. John's wort

This medicine may also interact with the following medications:

  • aminoglycosides

  • medicines for viral infections like adefovir, ledipasvir; sofosbuvir, sofosbuvir; velpatasvir.; sofosbuvir; velpatasvir; voxilaprevir, ribavirin, cidofovir, acyclovir, valacyclovir, ganciclovir, valganciclovir

  • NSAIDS, medicines for pain and inflammation, like ibuprofen or naproxen

  • other medicines for HIV

  • rifabutin

  • sorbitol

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store below 20 to 25 degrees C (68 to 77 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • bone problems

  • kidney disease

  • liver disease

  • an unusual or allergic reaction to doravirine, lamivudine, tenofovir, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular check ups. Discuss any new symptoms with your doctor. You will need to have important blood work done while on this medicine.

HIV is spread to others through sexual or blood contact. Talk to your doctor about how to stop the spread of HIV.

If you have hepatitis B, talk to your doctor if you plan to stop this medicine. The symptoms of hepatitis B may get worse if you stop this medicine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Avoid alcohol and mood altering (street) drugs while taking this medicine because they can make these side effects worse.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2019 Elsevier
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